Ebook Advances in Molecular Toxicology Chapter Two. Free Radical Metabolites in Arylamine Toxicity
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Published on: 2013-08-12
Released on: 2013-08-12
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Aromatic amines (also known as arylamines) form a very important class of xenobiotics. The arylamine substructure is found in pesticides, carcinogens, and drugs. It is therefore unsurprising that arylamine drugs possess varying degrees of toxicity which ultimately depend on dose, exposure, and the particular genetic makeup of the individual. Arylamines have been shown to undergo oxidation reactions to produce reactive metabolites. This chapter will focus on a subset of reactive metabolites which are the arylamine-free radical metabolites. A detailed discussion on how these free radical metabolites form is presented, and association between the latter and toxicity reactions are discussed. Particular emphasis is devoted to the subject of arylamine-induced blood dyscrasias and recent advances as well as future prospects in this area. Nitrobenzene (EHC 230 2003) - INCHEM 1. SUMMARY 1.1 Identity physical and chemical properties and analytical methods. Nitrobenzene is a colourless to pale yellow oily liquid with an odour resembling ... Chapter 33 - Toxicology - ilocis.org Chapter 33 - Toxicology INTRODUCTION. Ellen K. Silbergeld. Toxicology is the study of poisons or more comprehensively the identification and quantification of ...
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